Lentiviral Vector-Mediated Expression of Exoenzyme C3 Transferase Lowers Intraocular Pressure in Monkeys
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چکیده
منابع مشابه
Nanosponge-Mediated Drug Delivery Lowers Intraocular Pressure.
PURPOSE We examined the efficacy of an extended-release drug delivery system, nanosponge (NS) encapsulated compounds, administered intravitreally to lower intraocular pressure (IOP) in mice. METHODS Bilateral ocular hypertension was induced in mice by injecting microbeads into the anterior chamber. Hypertensive mice received NS loaded with ocular hypotensive drugs via intravitreal injection a...
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Introduction: Semaphorin 3A (Sema 3A) is a secreted protein, which plays an integral part in developing the nervous system. It has collapse activity on the growth cone of dorsal root ganglia. After the development of the nervous system, Sema 3A expression decreases. Neuropilin 1 is a membrane receptor of Sema 3A. When semaphorin binds to neuropilin 1, the recruitment of oligodendrocyte precurso...
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Clostridium botulinum C3 exoenzyme (C3) selectively inactivates RhoA/B/C GTPases by ADP-ribosylation. Based on this substrate specificity C3 is a well-established tool in cell biology. C3 is taken up by eukaryotic cells although lacking an uptake and translocation domain. Based on different approaches vimentin was identified as membranous C3-interaction partner by mass spectrometry. Vimentin in...
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The topical application of 8-bromo-3'-5'-cyclic guanosine monophosphate (8BrcGMP) produces significant decreases in intraocular pressure (IOP) in rabbit eyes. Maximum effects are obtained with a 4% concentration, and IOP is reduced significantly (P less than 0.001) between 30 and 240 min after administration of the agent. The decrease in IOP occurs without significant change in tonographic outf...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2019
ISSN: 1525-0016
DOI: 10.1016/j.ymthe.2019.04.021